| Gene Information | |
|---|---|
| Gene Name | IFNGIP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 785 |
| Protein Names | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q16666 |
| Gene Card | IFI16 |
| Uniprot ID | Q16666 |
| Pfam | PF02760; PF02758 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level). {ECO:0000269|PubMed:12894224}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2OQ0 (X-ray 2.00A ) 3B6Y (X-ray 2.35A ) 3RLN (X-ray 2.25A ) 3RLO (X-ray 1.80A ) 3RNU (X-ray 2.50A ) 4QGU (X-ray 2.54A ) |
| DBSNP | rs1057018 rs866484 rs11585341 rs1057027 rs1057028 rs6940 rs6940 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization. Localizes in the nucleus during human herpes simplex virus 1 (HHV-1) infection. |
| Mouse PG classification | NA |
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