| Gene Information | |
|---|---|
| Gene Name | LGALS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 135 |
| Protein Names | Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1) |
| Target Name | galectin-1 |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000100097 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P09382 |
| Gene Card | LGALS1 |
| Uniprot ID | P09382 |
| Pfam | PF00337 |
| In ASD | yes |
| Allosteric Prediction | yes (0.436667745) |
| Ortholog in Animals | Alpaca_ LGALS1 ( ortholog_one2one ) Dog_ LGALS1 ( ortholog_one2many ) GuineaPig_ LGALS1 ( ortholog_one2one ) Mouse_ Lgals1 ( ortholog_one2one ) Pig_ LGALS1 ( ortholog_one2one ) Rat_ Lgals1 ( ortholog_one2one ) Rabbit_ LGALS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LGALSL, GRIFIN, LGALS7, LGALS7B, LGALS3, LGALS4, LGALS12, LGALS8, LGALS2, LGALS13, LGALS14, LGALS16, LGALS9B, LGALS9, LGALS9C, CLC |
| Tissue | tricuspid.valve, vagina |
| Tissue Specificity | Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. {ECO:0000269|PubMed:18824694, ECO:0000269|PubMed:19497882}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1GZW (X-ray 1.70A ) 1W6M (X-ray 2.30A ) 1W6N (X-ray 1.65A ) 1W6O (X-ray 1.90A ) 1W6P (X-ray 1.80A ) 1W6Q (X-ray 2.10A ) 2KM2 (NMR - ) 2ZKN (X-ray 1.86A ) 3OY8 (X-ray 2.19A ) 3OYW (X-ray 2.50A ) 3T2T (X-ray 1.90A ) 3W58 (X-ray 1.58A ) 3W59 (X-ray 2.10A ) 4Q1P (X-ray 1.46A ) 4Q1R (X-ray 1.47A ) 4Q26 (X-ray 1.40A ) 4Q27 (X-ray 1.20A ) 4Q2F (X-ray 1.40A ) 4XBL (X-ray 1.93A ) 4Y1U (X-ray 1.76A ) 4Y1V (X-ray 2.32A ) 4Y1X (X-ray 2.45A ) 4Y1Y (X-ray 1.86A ) 4Y1Z (X-ray 2.23A ) 4Y20 (X-ray 2.20A ) 4Y22 (X-ray 2.50A ) 4Y24 (X-ray 2.32A ) 5MWT (X-ray 1.71A ) 5MWX (X-ray 1.29A ) 6B94 (X-ray 1.80A ) 6F83 (X-ray 2.20A ) 6M5Y (X-ray 1.38A ) 7LTA (X-ray 1.53A ) 7NML (X-ray 1.43A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14617626}. Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:32272059}. Note=Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}. |
| Mouse PG classification | NA |
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