| Gene Information | |
|---|---|
| Gene Name | GMDS |
| Organism | Homo sapiens (Human) |
| Gene Length | 372 |
| Protein Names | GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD) |
| Target Name | gdp-mannose 4,6 dehydratase |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000112699 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O60547 |
| Gene Card | GMDS |
| Uniprot ID | O60547 |
| Pfam | PF16363 |
| In ASD | yes |
| Allosteric Prediction | yes (0.47123704) |
| Ortholog in Animals | Alpaca_ GMDS ( ortholog_one2one ) GuineaPig_ GMDS ( ortholog_one2one ) Macaque_ GMDS ( ortholog_one2one ) Mouse_ Gmds ( ortholog_one2one ) Pig_ GMDS ( ortholog_one2one ) Rat_ Gmds ( ortholog_one2one ) Rabbit_ GMDS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HSD3B7, GFUS, HSD3B2, HSD3B1, SDR42E2, GALE, SDR42E1, TGDS, UXS1, NSDHL |
| Tissue | parotid.gland, submandibular.gland |
| Tissue Specificity | Highly expressed in pancreas and small intestine. Expressed in thymus, protstate, colon, heart, placenta, liver and kidney. Expressed at low levels in spleen, testis, brain and lung. {ECO:0000269|PubMed:9525924}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1T2A (X-ray 1.84A ) 5IN4 (X-ray 1.60A ) 5IN5 (X-ray 1.90A ) 6GPJ (X-ray 1.94A ) 6GPK (X-ray 1.47A ) 6GPL (X-ray 1.76A ) 6Q94 (X-ray 2.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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