| Gene Information | |
|---|---|
| Gene Name | AK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 227 |
| Protein Names | GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (AK 3) (Adenylate kinase 3 alpha-like 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000147853 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UIJ7 |
| Gene Card | AK3 |
| Uniprot ID | Q9UIJ7 |
| Pfam | PF05191 |
| In ASD | no |
| Allosteric Prediction | no (-0.088256781) |
| Ortholog in Animals | Alpaca_ AK3 ( ortholog_one2one ) GuineaPig_ AK3 ( ortholog_one2one ) Macaque_ AK3 ( ortholog_one2one ) Mouse_ Ak3 ( ortholog_one2one ) Pig_ AK3 ( ortholog_one2one ) Rat_ Ak3 ( ortholog_one2one ) |
| Ohnologs | AK4 |
| Paralogs | CMPK1, AK5, AK1, AK7, AK9, AK2, AK8, AK4, AK4P3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, skeletal muscle and liver, moderately expressed in pancreas and kidney, and weakly expressed in placenta, brain and lung. {ECO:0000269|PubMed:11485571}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZD8 (X-ray 1.48A ) 6ZJB (X-ray 1.82A ) 6ZJD (X-ray 1.75A ) 6ZJE (X-ray 1.48A ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03169, ECO:0000269|PubMed:11485571}. |
| Mouse PG classification | NA |
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