| Gene Information | |
|---|---|
| Gene Name | IFIT3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 490 |
| Protein Names | Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000119917 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O14879 |
| Gene Card | IFIT3 |
| Uniprot ID | O14879 |
| Pfam | PF13176; PF13181 |
| In ASD | no |
| Allosteric Prediction | no (-0.530637353) |
| Ortholog in Animals | Alpaca_ IFIT3 ( ortholog_one2one ) Dog_ IFIT3 ( ortholog_one2one ) GuineaPig_ IFIT3 ( ortholog_one2one ) Macaque_ IFIT3 ( ortholog_one2one ) Mouse_ Ifit3 ( ortholog_one2many ) Mouse_ Ifit3b ( ortholog_one2many ) Pig_ IFIT3 ( ortholog_one2one ) Rat_ Ifit3 ( ortholog_one2one ) Rabbit_ IFIT3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IFIT2, IFIT5, IFIT1B, IFIT1 |
| Tissue | NA |
| Tissue Specificity | Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver. {ECO:0000269|PubMed:18706081}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6C6K (X-ray 2.54A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:18706081}. Mitochondrion {ECO:0000269|PubMed:21813773}. |
| Mouse PG classification | NA |
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