| Gene Information | |
|---|---|
| Gene Name | ZBTB48 |
| Organism | Homo sapiens (Human) |
| Gene Length | 688 |
| Protein Names | Telomere zinc finger-associated protein (TZAP) (Krueppel-related zinc finger protein 3) (hKR3) (Zinc finger and BTB domain-containing protein 48) (Zinc finger protein 855) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000204859 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P10074 |
| Gene Card | ZBTB48 |
| Uniprot ID | P10074 |
| Pfam | PF00651; PF00096 |
| In ASD | no |
| Allosteric Prediction | no (-0.823168193) |
| Ortholog in Animals | Alpaca_ ZBTB48 ( ortholog_one2one ) Dog_ ZBTB48 ( ortholog_one2one ) GuineaPig_ ZBTB48 ( ortholog_one2one ) Macaque_ ZBTB48 ( ortholog_one2one ) Mouse_ Zbtb48 ( ortholog_one2one ) Pig_ ZBTB48 ( ortholog_one2one ) Rat_ Zbtb48 ( ortholog_one2one ) Rabbit_ ZBTB48 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ZNF208, ZBTB24, ZNF473, CTCFL, ZNF771, CTCF, ZNF184, ZFP92, ZNF747, ZNF764, ZNF84, ZNF729, ZNF99, ZNF569, ZNF827, ZNF91, ZNF107, ZNF785, ZNF497, ZNF526, ZNF420, ZNF594, ZBTB34, ZNF282, ZNF347, ZNF142, ZNF689, ZNF574, ZBTB37, ZNF845, ZNF688, ZNF160, ZNF665, ZNF48, ZNF181, ZNF302 |
| Tissue | NA |
| Tissue Specificity | Detected in adrenal gland and neuroblastoma. {ECO:0000269|PubMed:9516840}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3B84 (X-ray 1.74A ) 5YJ3 (X-ray 2.85A ) |
| DBSNP | rs2229330 |
| Subcellular location [CC] | Nucleus {ECO:0000305}. Chromosome, telomere {ECO:0000269|PubMed:28082411, ECO:0000269|PubMed:28500257}. Note=Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2 (PubMed:28082411). According to another report, binds telomeres regardless of their length (PubMed:28500257). {ECO:0000269|PubMed:28082411, ECO:0000269|PubMed:28500257}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |