Gene Information
Gene NameIFCR
OrganismHomo sapiens (Human)
Gene Length3623
Protein NamesCubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBNA
Gene CardCUBN
Uniprot IDO60494
PfamPF00431; PF00008; PF12947; PF07645
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityDetected in kidney cortex (at protein level) (PubMed:9572993). Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney. {ECO:0000269|PubMed:9572993}.
Pharmacological Animal Models0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.040000(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3KQ4  (X-ray  3.30A  )  6GJE  (X-ray  2.30A  ) 
DBSNP rs774556167  rs12259370  rs1801220  rs1801222  rs57335729  rs202153130  rs1801224  rs2228053  rs7905349  rs1228797857  rs11254354  rs1801227  rs121434430  rs200203056  rs1801231  rs141640975  rs74116778  rs1276708  rs2271462  rs201513648  rs41289305  rs147617753  rs2356590  rs62619939  rs144360241  rs1276712  rs529856485  rs779959064  rs2271460  rs11254274  rs3740168  rs138758085  rs1801237  rs2796835  rs776663892  rs1801238  rs45551835  rs45569534  rs1801239  rs1801240  rs370778353  rs150202444  rs111265129  rs752843169  rs201157846  rs1801230  rs7898873  rs764917718  rs1801232  rs775742147 
Subcellular location [CC]Apical cell membrane {ECO:0000250|UniProtKB:Q9JLB4};
Peripheral membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:29402915, ECO:0000269|PubMed:30523278};
Peripheral membrane protein {ECO:0000305, ECO:0000305|PubMed:30523278}. Membrane, coated pit {ECO:0000269|PubMed:14576052}. Endosome {ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:29402915}. Lysosome membrane {ECO:0000250|UniProtKB:O70244};
Peripheral membrane protein {ECO:0000305}. Note=Lacks a transmembrane domain and depends on interaction with AMN for location at the plasma membrane (PubMed:29402915, PubMed:30523278). Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells (By similarity). {ECO:0000250|UniProtKB:O70244, ECO:0000269|PubMed:29402915, ECO:0000269|PubMed:30523278}.
Mouse PG classificationNA
click here to return to the previous page