| Gene Information | |
|---|---|
| Gene Name | IF |
| Organism | Homo sapiens (Human) |
| Gene Length | 583 |
| Protein Names | Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P05156 |
| Gene Card | CFI |
| Uniprot ID | P05156 |
| Pfam | PF00057; PF00530; PF00089 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in the liver by hepatocytes (PubMed:6327681). Also present in other cells such as monocytes, fibroblasts or keratinocytes (PubMed:6444659, PubMed:17320177). {ECO:0000269|PubMed:17320177, ECO:0000269|PubMed:6327681, ECO:0000269|PubMed:6444659}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XRC (X-ray 2.69A ) 5O32 (X-ray 4.21A ) |
| DBSNP | rs773187287 rs141853578 rs75612300 rs121964916 rs182078921 rs11098044 rs121964917 rs769419740 rs61733901 rs121964912 rs121964918 rs121964914 |
| Subcellular location [CC] | Secreted, extracellular space. Secreted {ECO:0000269|PubMed:6327681}. |
| Mouse PG classification | NA |
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