| Gene Information | |
|---|---|
| Gene Name | NFASC |
| Organism | Homo sapiens (Human) |
| Gene Length | 1347 |
| Protein Names | Neurofascin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000163531 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O94856 |
| Gene Card | NFASC |
| Uniprot ID | O94856 |
| Pfam | PF13882; PF00041; PF07679; PF00047 |
| In ASD | no |
| Allosteric Prediction | yes (0.025673402) |
| Ortholog in Animals | Alpaca_ NFASC ( ortholog_one2one ) Dog_ NFASC ( ortholog_one2one ) GuineaPig_ NFASC ( ortholog_one2one ) Macaque_ NFASC ( ortholog_one2one ) Mouse_ Nfasc ( ortholog_one2one ) Pig_ NFASC ( ortholog_one2one ) Rat_ Nfasc ( ortholog_one2one ) Rabbit_ NFASC ( ortholog_one2one ) |
| Ohnologs | NRCAM, CHL1, L1CAM |
| Paralogs | CNTN5, CNTN2, ROBO2, SDK1, SDK2, CNTN3, HMCN2, CNTN6, DSCAML1, VSIG10L, CNTN1, IGDCC4, IGSF21, VCAM1, ROBO1, L1CAM, BOC, DCC, IGDCC3, ROBO4, IGSF9, VSIG10, DSCAM, CDON, NCAM1, ROBO3, CHL1, NRCAM, NEO1, IGSF9B, MXRA5, IGSF10, PTPRQ, NCAM2, PRTG, CNTN4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3P3Y (X-ray 2.60A ) 3P40 (X-ray 3.20A ) |
| DBSNP | rs3795564 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:30850329}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 8]: Cell junction, paranodal septate junction {ECO:0000269|PubMed:30124836}. |
| Mouse PG classification | NA |
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