| Gene Information | |
|---|---|
| Gene Name | IEGF |
| Organism | Homo sapiens (Human) |
| Gene Length | 370 |
| Protein Names | Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9GZP0 |
| Gene Card | PDGFD |
| Uniprot ID | Q9GZP0 |
| Pfam | PF00431; PF00341 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines. {ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:11331882, ECO:0000269|PubMed:11342471, ECO:0000269|PubMed:11980634, ECO:0000269|PubMed:12427128, ECO:0000269|PubMed:14514732, ECO:0000269|PubMed:15988036}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs35045740 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11331882}. Note=Released by platelets upon wounding. |
| Mouse PG classification | NA |
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