| Gene Information | |
|---|---|
| Gene Name | IDUA |
| Organism | Homo sapiens (Human) |
| Gene Length | 653 |
| Protein Names | Alpha-L-iduronidase (EC 3.2.1.76) |
| Target Name | alpha-l-iduronidase |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000127415 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P35475 |
| Gene Card | IDUA |
| Uniprot ID | P35475 |
| Pfam | PF01229 |
| In ASD | no |
| Allosteric Prediction | no (-0.573810841) |
| Ortholog in Animals | Alpaca_ IDUA ( ortholog_one2one ) Dog_ IDUA ( ortholog_one2one ) GuineaPig_ IDUA ( ortholog_one2one ) Macaque_ IDUA ( ortholog_one2one ) Mouse_ Idua ( ortholog_one2one ) Pig_ IDUA ( ortholog_one2one ) Rat_ Idua ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3W81 (X-ray 2.30A ) 3W82 (X-ray 2.76A ) 4KGJ (X-ray 2.99A ) 4KGL (X-ray 2.70A ) 4KH2 (X-ray 2.36A ) 4MJ2 (X-ray 2.10A ) 4MJ4 (X-ray 2.17A ) 4OBR (X-ray 2.46A ) 4OBS (X-ray 2.26A ) 6I6R (X-ray 2.02A ) 6I6X (X-ray 2.39A ) |
| DBSNP | rs794726878 rs10794537 rs794726877 rs758452450 rs780165694 rs747981483 rs794727239 rs148775298 rs121965029 rs754966840 rs3755955 rs148946496 rs558683362 rs992336192 rs754154200 rs1430681871 rs869025584 rs1230234600 rs148789453 rs369090960 rs121965030 rs199801029 rs121965033 rs746766617 rs368454909 rs6831280 rs750496798 rs121965024 rs762903007 rs754949360 rs1553917309 rs794727896 rs11934801 rs931627770 rs532731688 rs73066479 rs121965027 rs121965026 rs772416503 rs772416503 rs121965021 rs398123257 rs121965031 rs1281475543 rs200448421 |
| Subcellular location [CC] | Lysosome {ECO:0000305}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |