| Gene Information | |
|---|---|
| Gene Name | IDS |
| Organism | Homo sapiens (Human) |
| Gene Length | 550 |
| Protein Names | Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain] |
| Target Name | iduronate 2-sulfatase |
| Target Type | Successful target |
| Gene Age | 886 ( ENSG00000010404 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P22304 |
| Gene Card | IDS |
| Uniprot ID | P22304 |
| Pfam | PF00884 |
| In ASD | no |
| Allosteric Prediction | no (-0.023926966) |
| Ortholog in Animals | Alpaca_ IDS ( ortholog_one2one ) Dog_ IDS ( ortholog_one2one ) GuineaPig_ IDS ( ortholog_one2one ) Macaque_ IDS ( ortholog_one2one ) Mouse_ Ids ( ortholog_one2one ) Pig_ IDS ( ortholog_one2one ) Rat_ Ids ( ortholog_one2one ) Rabbit_ IDS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ARSA, ARSL, SULF1, STS, ARSI, ARSG, ARSH, SGSH, GALNS, SULF2, GNS, ARSB, ARSJ, ARSF, ARSD, ARSK |
| Tissue | NA |
| Tissue Specificity | Liver, kidney, lung, and placenta. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5FQL (X-ray 2.30A ) 6IOZ (X-ray 3.10A ) |
| DBSNP | rs1569560528 rs193302909 rs113993954 rs113993949 rs1557340280 rs398123249 rs2089497431 rs2089497300 rs483352905 rs193302911 rs193302911 rs104894861 rs104894856 rs398123250 rs864622779 rs193302905 rs146458524 rs1085308006 rs145807417 rs201048643 rs104894853 rs2089378583 rs199422229 rs199422229 rs1602725808 rs113993946 rs113993946 rs199422231 rs864622773 rs199422228 rs2089303696 |
| Subcellular location [CC] | Lysosome {ECO:0000269|PubMed:10838181}. |
| Mouse PG classification | NA |
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