| Gene Information | |
|---|---|
| Gene Name | IDO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 403 |
| Protein Names | Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase) |
| Target Name | indoleamine 2,3-dioxygenase 1 |
| Target Type | NA |
| Gene Age | 36 ( ENSG00000131203 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P14902 |
| Gene Card | IDO1 |
| Uniprot ID | P14902 |
| Pfam | PF01231 |
| In ASD | yes |
| Allosteric Prediction | yes (1.00000108) |
| Ortholog in Animals | Alpaca_ IDO1 ( ortholog_one2one ) Dog_ IDO1 ( ortholog_one2one ) GuineaPig_ IDO1 ( ortholog_one2one ) Macaque_ IDO1 ( ortholog_one2one ) Mouse_ Ido1 ( ortholog_one2one ) Pig_ IDO1 ( ortholog_one2one ) Rat_ Ido1 ( ortholog_one2one ) Rabbit_ IDO1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor-draining lymph nodes (PubMed:26155395, PubMed:25691885). {ECO:0000269|PubMed:18418598, ECO:0000269|PubMed:25691885, ECO:0000269|PubMed:26155395}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2D0T (X-ray 2.30A ) 2D0U (X-ray 3.40A ) 4PK5 (X-ray 2.79A ) 4PK6 (X-ray 3.45A ) 4U72 (X-ray 2.00A ) 4U74 (X-ray 2.31A ) 5EK2 (X-ray 2.68A ) 5EK3 (X-ray 2.21A ) 5EK4 (X-ray 2.64A ) 5ETW (X-ray 2.70A ) 5WHR (X-ray 2.28A ) 5WMU (X-ray 2.40A ) 5WMV (X-ray 2.60A ) 5WMW (X-ray 3.03A ) 5WMX (X-ray 2.69A ) 5WN8 (X-ray 2.50A ) 5XE1 (X-ray 3.20A ) 6AZU (X-ray 2.82A ) 6AZV (X-ray 2.75A ) 6AZW (X-ray 2.78A ) 6CXU (X-ray 2.49A ) 6CXV (X-ray 2.60A ) 6DPQ (X-ray 2.94A ) 6DPR (X-ray 3.20A ) 6E35 (X-ray 2.41A ) 6E40 (X-ray 2.31A ) 6E41 (X-ray 2.29A ) 6E42 (X-ray 2.10A ) 6E43 (X-ray 1.71A ) 6E44 (X-ray 1.90A ) 6E45 (X-ray 2.00A ) 6E46 (X-ray 2.09A ) 6F0A (X-ray 2.26A ) 6KOF (X-ray 2.26A ) 6KPS (X-ray 2.25A ) 6KW7 (X-ray 3.02A ) 6MQ6 (X-ray 3.05A ) 6O3I (X-ray 2.69A ) 6PU7 (X-ray 2.43A ) 6PZ1 (X-ray 2.65A ) 6R63 (X-ray 2.89A ) 6UBP (X-ray 2.95A ) 6V52 (X-ray 1.78A ) 6WJY (X-ray 1.91A ) 6WPE (X-ray 2.43A ) 6X5Y (X-ray 2.65A ) 7A62 (X-ray 2.44A ) 7AH4 (X-ray 2.40A ) 7AH5 (X-ray 2.90A ) 7AH6 (X-ray 3.00A ) 7B1O (X-ray 2.58A ) 7E0O (X-ray 3.34A ) 7E0P (X-ray 2.63A ) 7E0Q (X-ray 2.46A ) 7E0S (X-ray 2.71A ) 7E0T (X-ray 2.14A ) 7E0U (X-ray 2.28A ) 7M63 (X-ray 3.10A ) 7M7D (X-ray 2.60A ) 7NGE (X-ray 2.30A ) 7P0N (X-ray 2.50A ) 7P0R (X-ray 2.50A ) 7RRB (X-ray 2.69A ) 7RRC (X-ray 2.18A ) 7RRD (X-ray 2.76A ) 7ZV3 (X-ray 2.55A ) 8ABX (X-ray 1.65A ) |
| DBSNP | rs35059413 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P28776, ECO:0000303|PubMed:25691885}. |
| Mouse PG classification | NA |
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