Gene Information
Gene NameIDO
OrganismHomo sapiens (Human)
Gene Length403
Protein NamesIndoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP14902
Gene CardIDO1
Uniprot IDP14902
PfamPF01231
In ASDyes
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor-draining lymph nodes (PubMed:26155395, PubMed:25691885). {ECO:0000269|PubMed:18418598, ECO:0000269|PubMed:25691885, ECO:0000269|PubMed:26155395}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2D0T  (X-ray  2.30A  2D0U  (X-ray  3.40A  4PK5  (X-ray  2.79A  4PK6  (X-ray  3.45A  4U72  (X-ray  2.00A  4U74  (X-ray  2.31A  5EK2  (X-ray  2.68A  5EK3  (X-ray  2.21A  5EK4  (X-ray  2.64A  5ETW  (X-ray  2.70A  5WHR  (X-ray  2.28A  5WMU  (X-ray  2.40A  5WMV  (X-ray  2.60A  5WMW  (X-ray  3.03A  5WMX  (X-ray  2.69A  5WN8  (X-ray  2.50A  5XE1  (X-ray  3.20A  6AZU  (X-ray  2.82A  6AZV  (X-ray  2.75A  6AZW  (X-ray  2.78A  6CXU  (X-ray  2.49A  6CXV  (X-ray  2.60A  6DPQ  (X-ray  2.94A  6DPR  (X-ray  3.20A  6E35  (X-ray  2.41A  6E40  (X-ray  2.31A  6E41  (X-ray  2.29A  6E42  (X-ray  2.10A  6E43  (X-ray  1.71A  6E44  (X-ray  1.90A  6E45  (X-ray  2.00A  6E46  (X-ray  2.09A  6F0A  (X-ray  2.26A  6KOF  (X-ray  2.26A  6KPS  (X-ray  2.25A  6KW7  (X-ray  3.02A  6MQ6  (X-ray  3.05A  6O3I  (X-ray  2.69A  6PU7  (X-ray  2.43A  6PZ1  (X-ray  2.65A  6R63  (X-ray  2.89A  6UBP  (X-ray  2.95A  6V52  (X-ray  1.78A  6WJY  (X-ray  1.91A  6WPE  (X-ray  2.43A  6X5Y  (X-ray  2.65A  7A62  (X-ray  2.44A  7AH4  (X-ray  2.40A  7AH5  (X-ray  2.90A  7AH6  (X-ray  3.00A  7B1O  (X-ray  2.58A  7E0O  (X-ray  3.34A  7E0P  (X-ray  2.63A  7E0Q  (X-ray  2.46A  7E0S  (X-ray  2.71A  7E0T  (X-ray  2.14A  7E0U  (X-ray  2.28A  7M63  (X-ray  3.10A  7M7D  (X-ray  2.60A  7NGE  (X-ray  2.30A  7P0N  (X-ray  2.50A  7P0R  (X-ray  2.50A  7RRB  (X-ray  2.69A  7RRC  (X-ray  2.18A  7RRD  (X-ray  2.76A  7ZV3  (X-ray  2.55A  8ABX  (X-ray  1.65A 
DBSNP rs35059413 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000250|UniProtKB:P28776, ECO:0000303|PubMed:25691885}.
Mouse PG classificationNA
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