| Gene Information | |
|---|---|
| Gene Name | IDH3A |
| Organism | Homo sapiens (Human) |
| Gene Length | 366 |
| Protein Names | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) |
| Target Name | isocitrate dehydrogenase [nad] subunit alpha, mitochondrial |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000166411 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P50213 |
| Gene Card | IDH3A |
| Uniprot ID | P50213 |
| Pfam | PF00180 |
| In ASD | yes |
| Allosteric Prediction | yes (1.187801006) |
| Ortholog in Animals | Alpaca_ IDH3A ( ortholog_one2one ) Dog_ IDH3A ( ortholog_one2one ) GuineaPig_ IDH3A ( ortholog_one2one ) Macaque_ IDH3A ( ortholog_one2one ) Mouse_ Idh3a ( ortholog_one2one ) Pig_ IDH3A ( ortholog_one2one ) Rat_ Idh3a ( ortholog_one2one ) Rabbit_ IDH3A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IDH3G, IDH3B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.760143(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5GRE (X-ray 2.65A ) 5GRF (X-ray 2.50A ) 5GRH (X-ray 2.80A ) 5GRI (X-ray 2.31A ) 5GRL (X-ray 2.79A ) 5YVT (X-ray 2.40A ) 6KDE (X-ray 3.00A ) 6KDF (X-ray 3.05A ) 6KDY (X-ray 3.02A ) 6KE3 (X-ray 3.31A ) 6L57 (X-ray 2.30A ) 6L59 (X-ray 2.25A ) 7CE3 (X-ray 3.47A ) |
| DBSNP | rs756333430 rs765473830 rs756712426 rs149862950 rs770798851 |
| Subcellular location [CC] | Mitochondrion. |
| Mouse PG classification | NA |
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