| Gene Information | |
|---|---|
| Gene Name | IDH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 452 |
| Protein Names | Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) |
| Target Name | isocitrate dehydrogenase [nadp], mitochondrial |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000182054 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P48735 |
| Gene Card | IDH2 |
| Uniprot ID | P48735 |
| Pfam | PF00180 |
| In ASD | yes |
| Allosteric Prediction | yes (1.155881399) |
| Ortholog in Animals | Alpaca_ IDH2 ( ortholog_one2one ) Dog_ IDH2 ( ortholog_one2one ) GuineaPig_ IDH2 ( ortholog_one2one ) Macaque_ IDH2 ( ortholog_one2one ) Mouse_ Idh2 ( ortholog_one2one ) Pig_ IDH2 ( ortholog_one2one ) Rat_ Idh2 ( ortholog_one2one ) Rabbit_ IDH2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IDH1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4JA8 (X-ray 1.55A ) 5GIS (X-ray 1.93A ) 5I95 (X-ray 1.54A ) 5I96 (X-ray 1.55A ) 5SVN (X-ray 2.10A ) 5SVO (X-ray 1.87A ) 6ADI (X-ray 1.97A ) 6UJ7 (X-ray 1.90A ) 6UJ8 (X-ray 2.25A ) 6UJ9 (X-ray 2.90A ) 6VFZ (X-ray 1.99A ) |
| DBSNP | rs267606870 rs121913502 rs1057519906 rs121913503 rs121913503 rs1057519736 rs1057519906 |
| Subcellular location [CC] | Mitochondrion {ECO:0000250|UniProtKB:P33198}. |
| Mouse PG classification | NA |
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