| Gene Information | |
|---|---|
| Gene Name | IDH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 414 |
| Protein Names | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) |
| Target Name | mutated oxalosuccinate decarboxylase |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000138413 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O75874 |
| Gene Card | IDH1 |
| Uniprot ID | O75874 |
| Pfam | PF00180 |
| In ASD | yes |
| Allosteric Prediction | yes (1.291062721) |
| Ortholog in Animals | Alpaca_ IDH1 ( ortholog_one2one ) Dog_ IDH1 ( ortholog_one2one ) GuineaPig_ IDH1 ( ortholog_one2one ) Macaque_ IDH1 ( ortholog_one2one ) Mouse_ Idh1 ( ortholog_one2one ) Pig_ IDH1 ( ortholog_one2one ) Rat_ Idh1 ( ortholog_one2one ) Rabbit_ IDH1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IDH2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.044155(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1T09 (X-ray 2.70A ) 1T0L (X-ray 2.41A ) 3INM (X-ray 2.10A ) 3MAP (X-ray 2.80A ) 3MAR (X-ray 3.41A ) 3MAS (X-ray 3.20A ) 4I3K (X-ray 3.31A ) 4I3L (X-ray 3.29A ) 4KZO (X-ray 2.20A ) 4L03 (X-ray 2.10A ) 4L04 (X-ray 2.87A ) 4L06 (X-ray 2.28A ) 4UMX (X-ray 1.88A ) 4UMY (X-ray 2.07A ) 4XRX (X-ray 3.20A ) 4XS3 (X-ray 3.29A ) 5DE1 (X-ray 2.25A ) 5GIR (X-ray 1.93A ) 5K10 (EM 3.80A ) 5K11 (EM 3.80A ) 5L57 (X-ray 2.69A ) 5L58 (X-ray 3.04A ) 5LGE (X-ray 2.70A ) 5SUN (X-ray 2.48A ) 5SVF (X-ray 2.34A ) 5TQH (X-ray 2.20A ) 5YFM (X-ray 2.40A ) 5YFN (X-ray 2.50A ) 6ADG (X-ray 3.00A ) 6B0Z (X-ray 2.33A ) 6BKX (X-ray 1.65A ) 6BKY (X-ray 2.17A ) 6BKZ (X-ray 2.01A ) 6BL0 (X-ray 2.17A ) 6BL1 (X-ray 2.02A ) 6BL2 (X-ray 1.92A ) 6IO0 (X-ray 2.20A ) 6O2Y (X-ray 2.80A ) 6O2Z (X-ray 2.50A ) 6PAY (X-ray 2.20A ) 6Q6F (X-ray 3.30A ) 6U4J (X-ray 2.11A ) 6VEI (X-ray 2.10A ) 6VG0 (X-ray 2.66A ) 7PJM (X-ray 2.10A ) 7PJN (X-ray 2.45A ) |
| DBSNP | rs121913499 rs121913499 rs121913500 rs121913500 rs121913499 rs34218846 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:10521434}. Peroxisome {ECO:0000269|PubMed:10521434}. |
| Mouse PG classification | NA |
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