| Gene Information | |
|---|---|
| Gene Name | IDE |
| Organism | Homo sapiens (Human) |
| Gene Length | 1019 |
| Protein Names | Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin) |
| Target Name | insulin-degrading enzyme |
| Target Type | Successful target |
| Gene Age | 1714 ( ENSG00000119912 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P14735 |
| Gene Card | IDE |
| Uniprot ID | P14735 |
| Pfam | PF00675; PF05193; PF16187 |
| In ASD | yes |
| Allosteric Prediction | yes (1.037636325) |
| Ortholog in Animals | Alpaca_ IDE ( ortholog_one2one ) Dog_ IDE ( ortholog_one2one ) GuineaPig_ IDE ( ortholog_one2one ) Macaque_ IDE ( ortholog_one2one ) Mouse_ Ide ( ortholog_one2one ) Pig_ IDE ( ortholog_one2one ) Rat_ Ide ( ortholog_one2one ) Rabbit_ IDE ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PMPCA, UQCRC1, PITRM1, NRDC, UQCRC2, PMPCB |
| Tissue | testis |
| Tissue Specificity | Detected in brain and in cerebrospinal fluid (at protein level). {ECO:0000269|PubMed:9830016}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2G47 (X-ray 2.10A ) 2G48 (X-ray 2.60A ) 2G49 (X-ray 2.50A ) 2G54 (X-ray 2.25A ) 2G56 (X-ray 2.20A ) 2JBU (X-ray 3.00A ) 2JG4 (X-ray 2.80A ) 2WBY (X-ray 2.60A ) 2WC0 (X-ray 2.80A ) 2WK3 (X-ray 2.59A ) 2YPU (X-ray 2.80A ) 3CWW (X-ray 1.96A ) 3E4A (X-ray 2.60A ) 3E4Z (X-ray 2.28A ) 3E50 (X-ray 2.30A ) 3H44 (X-ray 3.00A ) 3HGZ (X-ray 2.91A ) 3N56 (X-ray 3.10A ) 3N57 (X-ray 3.03A ) 3OFI (X-ray 2.35A ) 3QZ2 (X-ray 3.20A ) 4DTT (X-ray 3.22A ) 4DWK (X-ray 3.00A ) 4GS8 (X-ray 2.99A ) 4GSC (X-ray 2.81A ) 4GSF (X-ray 2.70A ) 4IFH (X-ray 3.29A ) 4IOF (X-ray 3.35A ) 4LTE (X-ray 2.70A ) 4M1C (X-ray 3.50A ) 4NXO (X-ray 2.73A ) 4PES (X-ray 2.21A ) 4PF7 (X-ray 2.33A ) 4PF9 (X-ray 2.50A ) 4PFC (X-ray 2.21A ) 4QIA (X-ray 3.20A ) 4RAL (X-ray 3.15A ) 4RE9 (X-ray 2.91A ) 5CJO (X-ray 3.29A ) 5UOE (X-ray 3.80A ) 5WOB (X-ray 3.95A ) 6B3Q (EM 3.70A ) 6B70 (EM 3.70A ) 6B7Y (EM 6.50A ) 6B7Z (EM 6.50A ) 6BF6 (EM 6.50A ) 6BF7 (EM 6.50A ) 6BF8 (EM 4.20A ) 6BF9 (EM 7.20A ) 6BFC (EM 3.70A ) 6BYZ (X-ray 2.96A ) 6EDS (X-ray 3.18A ) 6MQ3 (X-ray 3.57A ) 7K1D (X-ray 3.00A ) 7K1E (X-ray 2.80A ) 7K1F (X-ray 2.60A ) 7RZE (EM 3.30A ) 7RZF (EM 3.40A ) 7RZG (EM 4.10A ) 7RZH (EM 3.80A ) 7RZI (EM 3.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:20364150, ECO:0000269|PubMed:9830016}. Cell membrane {ECO:0000250|UniProtKB:P35559}. Secreted {ECO:0000269|PubMed:9830016}. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform. |
| Mouse PG classification | NA |
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