| Gene Information | |
|---|---|
| Gene Name | RPS6KB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 525 |
| Protein Names | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) |
| Target Name | ribosomal protein s6 kinase beta-1 |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000108443 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P23443 |
| Gene Card | RPS6KB1 |
| Uniprot ID | P23443 |
| Pfam | PF00069; PF00433 |
| In ASD | yes |
| Allosteric Prediction | yes (1.048205911) |
| Ortholog in Animals | Alpaca_ RPS6KB1 ( ortholog_one2one ) Dog_ RPS6KB1 ( ortholog_one2one ) GuineaPig_ RPS6KB1 ( ortholog_one2one ) Macaque_ RPS6KB1 ( ortholog_one2one ) Mouse_ Rps6kb1 ( ortholog_one2one ) Pig_ RPS6KB1 ( ortholog_one2one ) Rat_ Rps6kb1 ( ortholog_one2one ) Rabbit_ RPS6KB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RPS6KA1, RPS6KA5, RPS6KA3, RPS6KA2, RPS6KB2, RPS6KA4, RPS6KA6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9804755}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.034783(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3A60 (X-ray 2.80A ) 3A61 (X-ray 3.43A ) 3A62 (X-ray 2.35A ) 3WE4 (X-ray 2.00A ) 3WF5 (X-ray 2.10A ) 3WF6 (X-ray 2.03A ) 3WF7 (X-ray 1.85A ) 3WF8 (X-ray 1.98A ) 3WF9 (X-ray 2.04A ) 4L3J (X-ray 2.10A ) 4L3L (X-ray 2.10A ) 4L42 (X-ray 2.80A ) 4L43 (X-ray 3.00A ) 4L44 (X-ray 2.90A ) 4L45 (X-ray 2.90A ) 4L46 (X-ray 3.01A ) 4RLO (X-ray 2.53A ) 4RLP (X-ray 2.79A ) 5WBH (X-ray 1.75A ) 5WBK (X-ray 3.11A ) 7N91 (X-ray 3.00A ) 7N93 (X-ray 2.74A ) |
| DBSNP | rs766645749 |
| Subcellular location [CC] | Synapse, synaptosome {ECO:0000250}. Mitochondrion outer membrane. Mitochondrion. Note=Colocalizes with URI1 at mitochondrion.; [Isoform Alpha I]: Nucleus. Cytoplasm.; [Isoform Alpha II]: Cytoplasm. |
| Mouse PG classification | NA |
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