| Gene Information | |
|---|---|
| Gene Name | ICOS |
| Organism | Homo sapiens (Human) |
| Gene Length | 199 |
| Protein Names | Inducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD antigen CD278) |
| Target Name | inducible t-cell costimulator |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000163600 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9Y6W8 |
| Gene Card | ICOS |
| Uniprot ID | Q9Y6W8 |
| Pfam | PF15910 |
| In ASD | no |
| Allosteric Prediction | no (-0.85601044) |
| Ortholog in Animals | Alpaca_ ICOS ( ortholog_one2one ) Dog_ ICOS ( ortholog_one2one ) GuineaPig_ ICOS ( ortholog_one2one ) Macaque_ ICOS ( ortholog_one2one ) Mouse_ Icos ( ortholog_one2one ) Pig_ ICOS ( ortholog_one2one ) Rat_ Icos ( ortholog_one2one ) Rabbit_ ICOS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | appendix, bone.marrow, lymph.node, tonsil |
| Tissue Specificity | Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. {ECO:0000269|PubMed:11006126, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6X4G (X-ray 3.50A ) 7JOO (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [Isoform 2]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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