| Gene Information | |
|---|---|
| Gene Name | ICMT |
| Organism | Homo sapiens (Human) |
| Gene Length | 284 |
| Protein Names | Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000116237 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60725 |
| Gene Card | ICMT |
| Uniprot ID | O60725 |
| Pfam | PF04140 |
| In ASD | no |
| Allosteric Prediction | yes (0.052988032) |
| Ortholog in Animals | Alpaca_ ICMT ( ortholog_one2one ) GuineaPig_ ICMT ( ortholog_one2one ) Macaque_ ICMT ( ortholog_one2one ) Mouse_ Icmt ( ortholog_one2one ) Pig_ ICMT ( ortholog_one2one ) Rat_ Icmt ( ortholog_one2one ) Rabbit_ ICMT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons. {ECO:0000269|PubMed:10649571}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:19158273, ECO:0000269|PubMed:9614111}; Multi-pass membrane protein {ECO:0000269|PubMed:19158273}. |
| Mouse PG classification | NA |
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