| Gene Information | |
|---|---|
| Gene Name | ICE2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 982 |
| Protein Names | Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000128915 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q659A1 |
| Gene Card | ICE2 |
| Uniprot ID | Q659A1 |
| Pfam | PF10505 |
| In ASD | no |
| Allosteric Prediction | no (-0.338674231) |
| Ortholog in Animals | Alpaca_ ICE2 ( ortholog_one2one ) Dog_ ICE2 ( ortholog_one2one ) GuineaPig_ ICE2 ( ortholog_one2one ) Macaque_ ICE2 ( ortholog_one2one ) Mouse_ Ice2 ( ortholog_one2one ) Pig_ ICE2 ( ortholog_one2one ) Rat_ Ice2 ( ortholog_one2one ) Rabbit_ ICE2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at low levels in lung and testis. {ECO:0000269|PubMed:15606750}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:23932780}. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes. |
| Mouse PG classification | NA |
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