Gene Information
Gene NameICA512
OrganismHomo sapiens (Human)
Gene Length979
Protein NamesReceptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ16849
Gene CardPTPRN
Uniprot IDQ16849
PfamPF11548; PF14948; PF00102
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary. {ECO:0000269|PubMed:8024693}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2I1Y  (X-ray  2.23A  )  2QT7  (X-ray  1.30A  )  3N01  (X-ray  1.30A  )  3N4W  (X-ray  1.45A  )  3NG8  (X-ray  1.35A  )  3NP5  (X-ray  1.80A  ) 
DBSNP rs35314717 
Subcellular location [CC]Membrane {ECO:0000250|UniProtKB:Q63259};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q63259}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:25561468};
Single-pass type I membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q63259}. Cell projection, axon {ECO:0000250|UniProtKB:Q63259}. Synapse {ECO:0000250|UniProtKB:Q63259}. Cell membrane {ECO:0000269|PubMed:10457160};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q63259}. Endosome {ECO:0000250|UniProtKB:Q63259}. Note=Detected on neuronal secretory vesicles, but not on synaptic vesicles. Colocalizes with insulin-containing secretory granules (PubMed:25561468). Primarily detected on secretory vesicle membranes. Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles via the Golgi apparatus membranes. {ECO:0000250|UniProtKB:Q63259, ECO:0000269|PubMed:25561468}.;
[ICA512-transmembrane fragment]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q63259}.;
[ICA512-cleaved cytosolic fragment]: Nucleus {ECO:0000269|PubMed:15596545}.
Mouse PG classificationNA
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