| Gene Information | |
|---|---|
| Gene Name | CASS4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 786 |
| Protein Names | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000087589 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NQ75 |
| Gene Card | CASS4 |
| Uniprot ID | Q9NQ75 |
| Pfam | PF12026; PF08824; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.721374821) |
| Ortholog in Animals | Alpaca_ CASS4 ( ortholog_one2one ) Dog_ CASS4 ( ortholog_one2one ) GuineaPig_ CASS4 ( ortholog_one2one ) Macaque_ CASS4 ( ortholog_one2one ) Mouse_ Cass4 ( ortholog_one2one ) Pig_ CASS4 ( ortholog_one2one ) Rat_ Cass4 ( ortholog_one2one ) Rabbit_ CASS4 ( ortholog_one2one ) |
| Ohnologs | BCAR1, NEDD9 |
| Paralogs | NEDD9, EFS, BCAR1 |
| Tissue | NA |
| Tissue Specificity | Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines. {ECO:0000269|PubMed:18256281}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CRE (NMR - ) |
| DBSNP | rs16979936 rs6069755 rs35031530 rs7272702 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18256281}. Cell junction, focal adhesion {ECO:0000269|PubMed:18256281}. |
| Mouse PG classification | NA |
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