| Gene Information | |
|---|---|
| Gene Name | TRAPPC14 |
| Organism | Homo sapiens (Human) |
| Gene Length | 580 |
| Protein Names | Trafficking protein particle complex subunit 14 (Microtubule-associated protein 11) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000146826 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8WVR3 |
| Gene Card | TRAPPC14 |
| Uniprot ID | Q8WVR3 |
| Pfam | PF15806 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | Alpaca_ TRAPPC14 ( ortholog_one2one ) GuineaPig_ TRAPPC14 ( ortholog_one2one ) Macaque_ TRAPPC14 ( ortholog_one2one ) Mouse_ Trappc14 ( ortholog_one2one ) Pig_ TRAPPC14 ( ortholog_one2one ) Rat_ Trappc14 ( ortholog_one2one ) Rabbit_ TRAPPC14 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Broadly expressed. High levels in brain, cerebellum, testis and whole blood. {ECO:0000269|PubMed:30715179}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2293477 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:30715179}. Vesicle {ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}. Midbody {ECO:0000269|PubMed:30715179}. Cytoplasm {ECO:0000269|PubMed:31467083}. Note=During mitosis, precedes alpha-tubulin in gap formation of cell abscission at the midbody and is co-localized with PLK1 at the edges of microtubules extensions of daughter cells post cytokinesis abscission (PubMed:30715179). Colocalizes with RAB3IP on preciliary vesicles (PubMed:31467083). {ECO:0000269|PubMed:30715179, ECO:0000269|PubMed:31467083}. |
| Mouse PG classification | NA |
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