| Gene Information | |
|---|---|
| Gene Name | STOML2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 356 |
| Protein Names | Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000165283 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9UJZ1 |
| Gene Card | STOML2 |
| Uniprot ID | Q9UJZ1 |
| Pfam | PF01145; PF16200 |
| In ASD | no |
| Allosteric Prediction | no (-0.221025601) |
| Ortholog in Animals | Alpaca_ STOML2 ( ortholog_one2one ) Dog_ STOML2 ( ortholog_one2one ) GuineaPig_ STOML2 ( ortholog_one2one ) Macaque_ STOML2 ( ortholog_one2one ) Mouse_ Stoml2 ( ortholog_one2one ) Pig_ STOML2 ( ortholog_one2one ) Rat_ Stoml2 ( ortholog_one2one ) Rabbit_ STOML2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | STOML3, NPHS2, STOML1, STOM |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level). {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:11435687, ECO:0000269|PubMed:18641330}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001704(Rat);0.030769(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17856326 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}; Peripheral membrane protein {ECO:0000269|PubMed:10713127}. Mitochondrion {ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:22623988}. Mitochondrion inner membrane {ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18339324, ECO:0000269|PubMed:21746876}; Lipid-anchor {ECO:0000269|PubMed:21746876}. Mitochondrion intermembrane space {ECO:0000269|PubMed:17121834}. Membrane raft {ECO:0000269|PubMed:18641330}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330}. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain (PubMed:21746876). Also associates with the actin cytoskeleton and membrane rafts in activated T-cells (PubMed:18641330, PubMed:10713127). A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells (PubMed:22623988). {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}. |
| Mouse PG classification | NA |
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