| Gene Information | |
|---|---|
| Gene Name | IAPP |
| Organism | Homo sapiens (Human) |
| Gene Length | 89 |
| Protein Names | Islet amyloid polypeptide (Amylin) (Diabetes-associated peptide) (DAP) (Insulinoma amyloid peptide) |
| Target Name | islet amyloid polypeptide |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000121351 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P10997 |
| Gene Card | IAPP |
| Uniprot ID | P10997 |
| Pfam | PF00214 |
| In ASD | no |
| Allosteric Prediction | yes (0.012790142) |
| Ortholog in Animals | Alpaca_ IAPP ( ortholog_one2one ) Dog_ IAPP ( ortholog_one2one ) GuineaPig_ IAPP ( ortholog_one2one ) Macaque_ IAPP ( ortholog_one2one ) Mouse_ Iapp ( ortholog_one2one ) Rat_ Iapp ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CALCB, CALCA |
| Tissue | pancreas |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1KUW (NMR - ) 2G48 (X-ray 2.60A ) 2KB8 (NMR - ) 2L86 (NMR - ) 3DG1 (X-ray 1.66A ) 3FPO (X-ray 1.50A ) 3FR1 (X-ray 1.85A ) 3FTH (X-ray 1.84A ) 3FTK (X-ray 1.50A ) 3FTL (X-ray 1.60A ) 3FTR (X-ray 1.61A ) 3G7V (X-ray 1.86A ) 3G7W (X-ray 1.75A ) 3HGZ (X-ray 2.91A ) 5K5G (NMR - ) 5KNZ (EM 1.90A ) 5KO0 (EM 1.40A ) 5MGQ (NMR - ) 6UCJ (NMR - ) 6UCK (NMR - ) 6VW2 (EM 3.40A ) 6Y1A (EM 4.20A ) 6ZRF (EM 3.60A ) 6ZRQ (EM 3.90A ) 6ZRR (EM 4.00A ) 7BG0 (X-ray 2.89A ) 7M61 (EM 3.80A ) 7M62 (EM 3.90A ) 7M64 (EM 4.00A ) 7M65 (EM 4.10A ) |
| DBSNP | rs1800203 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:17374526}. |
| Mouse PG classification | NA |
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