| Gene Information | |
|---|---|
| Gene Name | EIF4E |
| Organism | Homo sapiens (Human) |
| Gene Length | 217 |
| Protein Names | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) |
| Target Name | eif4e messenger rna |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000151247 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P06730 |
| Gene Card | EIF4E |
| Uniprot ID | P06730 |
| Pfam | PF01652 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999921527) |
| Ortholog in Animals | Alpaca_ EIF4E ( ortholog_one2one ) Alpaca_ EIF4E ( ortholog_one2many ) GuineaPig_ EIF4E ( ortholog_one2one ) Macaque_ EIF4E ( ortholog_one2one ) Mouse_ Eif4e ( ortholog_one2one ) Pig_ EIF4E ( ortholog_one2one ) Rat_ Eif4e ( ortholog_one2one ) Rabbit_ EIF4E ( ortholog_one2one ) |
| Ohnologs | EIF4E1B |
| Paralogs | EIF4E2, EIF4E3, EIF4E1B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IPB (X-ray 2.00A ) 1IPC (X-ray 2.00A ) 1WKW (X-ray 2.10A ) 2GPQ (NMR - ) 2V8W (X-ray 2.30A ) 2V8X (X-ray 2.30A ) 2V8Y (X-ray 2.10A ) 2W97 (X-ray 2.29A ) 3AM7 (X-ray 2.20A ) 3TF2 (X-ray 2.10A ) 3U7X (X-ray 2.10A ) 4AZA (X-ray 2.16A ) 4BEA (X-ray 2.57A ) 4DT6 (X-ray 2.60A ) 4DUM (X-ray 2.95A ) 4TPW (X-ray 1.50A ) 4TQB (X-ray 1.59A ) 4TQC (X-ray 1.80A ) 4UED (X-ray 1.75A ) 5EHC (X-ray 2.40A ) 5EI3 (X-ray 1.71A ) 5EIR (X-ray 2.69A ) 5EKV (X-ray 3.61A ) 5GW6 (X-ray 1.97A ) 5T46 (X-ray 1.53A ) 5ZJY (X-ray 1.59A ) 5ZJZ (X-ray 1.67A ) 5ZK5 (X-ray 2.25A ) 5ZK7 (X-ray 2.12A ) 5ZK9 (X-ray 1.76A ) 5ZML (X-ray 1.80A ) 7D6Y (X-ray 1.67A ) 7D8B (X-ray 2.46A ) 7EZW (X-ray 2.35A ) 7F07 (X-ray 2.25A ) 7MEU (X-ray 1.91A ) 7XTP (X-ray 1.83A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, P-body {ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:25923732}. Cytoplasm {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:21883093}. Cytoplasm, Stress granule {ECO:0000269|PubMed:21883093}. Nucleus {ECO:0000269|PubMed:10856257}. Note=Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:25923732). Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:10856257). {ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:25923732}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |