| Gene Information | |
|---|---|
| Gene Name | RHOXF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 184 |
| Protein Names | Rhox homeobox family member 1 (Ovary-, testis- and epididymis-expressed gene protein) (Paired-like homeobox protein PEPP-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000101883 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8NHV9 |
| Gene Card | RHOXF1 |
| Uniprot ID | Q8NHV9 |
| Pfam | PF00046 |
| In ASD | no |
| Allosteric Prediction | no (-0.870884204) |
| Ortholog in Animals | Macaque_ RHOXF1 ( ortholog_one2one ) Mouse_ Rhox13 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, PITX3, PRRX1, SHOX, SHOX2, PRRX2, OTX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, PHOX2B, EVX2, ALX1, VSX2, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | cerebellar.hemisphere, cerebellum, testis |
| Tissue Specificity | Ovary, testis and epididymis. Also detected in the prostate and the mammary gland. Expressed in many tumor cell lines derived from acute lymphocytic leukemia, prostate, endometrial adenocarcinoma, melanoma, bladder carcinoma, colon carcinoma, erythroleukemia and breast carcinoma. Not expressed in placenta. In testis, mainly expressed in germ cells, but also detected in somatic cells such as Sertoli cells, Leydig cells and peritubular cells (PubMed:28171660). {ECO:0000269|PubMed:12490318, ECO:0000269|PubMed:28171660}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2301977 rs138060880 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11980563}. |
| Mouse PG classification | NA |
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