| Gene Information | |
|---|---|
| Gene Name | HYL |
| Organism | Homo sapiens (Human) |
| Gene Length | 507 |
| Protein Names | Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P42679 |
| Gene Card | MATK |
| Uniprot ID | P42679 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in various myeloid cell lines, detected in brain and lung. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.025650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JWO (X-ray 2.50A ) 1X6G (NMR - ) 3US4 (X-ray 1.50A ) |
| DBSNP | rs35351680 rs778726488 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9171348}. Membrane {ECO:0000269|PubMed:9171348}. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation. |
| Mouse PG classification | NA |
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