| Gene Information | |
|---|---|
| Gene Name | KLB |
| Organism | Homo sapiens (Human) |
| Gene Length | 1044 |
| Protein Names | Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein) |
| Target Name | beta-klotho |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000134962 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q86Z14 |
| Gene Card | KLB |
| Uniprot ID | Q86Z14 |
| Pfam | PF00232 |
| In ASD | no |
| Allosteric Prediction | yes (0.056211119) |
| Ortholog in Animals | Alpaca_ KLB ( ortholog_one2one ) Dog_ KLB ( ortholog_one2one ) GuineaPig_ KLB ( ortholog_one2one ) Macaque_ KLB ( ortholog_one2one ) Mouse_ Klb ( ortholog_one2one ) Pig_ KLB ( ortholog_one2one ) Rat_ Klb ( ortholog_one2one ) Rabbit_ KLB ( ortholog_one2one ) |
| Ohnologs | KL, LCT |
| Paralogs | LCT, GBA3, LCTL, KL |
| Tissue | adipose.tissue, liver, testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5VAK (X-ray 1.70A ) 5VAN (X-ray 2.20A ) 5VAQ (X-ray 2.61A ) 5WI9 (X-ray 2.70A ) 6NFJ (X-ray 3.19A ) |
| DBSNP | rs34905034 rs17618244 rs35372803 rs17618262 rs4975017 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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