| Gene Information | |
|---|---|
| Gene Name | NOXO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 376 |
| Protein Names | NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5) |
| Target Name | nadph oxidase organizer 1 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000196408 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8NFA2 |
| Gene Card | NOXO1 |
| Uniprot ID | Q8NFA2 |
| Pfam | PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.683091947) |
| Ortholog in Animals | Alpaca_ NOXO1 ( ortholog_one2one ) Dog_ NOXO1 ( ortholog_one2one ) GuineaPig_ NOXO1 ( ortholog_one2one ) Macaque_ NOXO1 ( ortholog_one2one ) Mouse_ Noxo1 ( ortholog_one2one ) Pig_ NOXO1 ( ortholog_one2one ) Rat_ Noxo1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NCF1, SH3PXD2B, SH3PXD2A |
| Tissue | NA |
| Tissue Specificity | Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15949904}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2L73 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 3]: Cell membrane {ECO:0000269|PubMed:12716910}; Peripheral membrane protein {ECO:0000269|PubMed:12716910}; Cytoplasmic side {ECO:0000269|PubMed:12716910}. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910). |
| Mouse PG classification | NA |
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