| Gene Information | |
|---|---|
| Gene Name | SERPINE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 402 |
| Protein Names | Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1) |
| Target Name | endothelial plasminogen activator inhibitor |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000106366 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P05121 |
| Gene Card | SERPINE1 |
| Uniprot ID | P05121 |
| Pfam | PF00079 |
| In ASD | yes |
| Allosteric Prediction | yes (1.358725652) |
| Ortholog in Animals | Alpaca_ SERPINE1 ( ortholog_one2one ) Dog_ SERPINE1 ( ortholog_one2one ) GuineaPig_ SERPINE1 ( ortholog_one2one ) Macaque_ SERPINE1 ( ortholog_one2one ) Mouse_ Serpine1 ( ortholog_one2one ) Pig_ SERPINE1 ( ortholog_one2one ) Rat_ Serpine1 ( ortholog_one2one ) Rabbit_ SERPINE1 ( ortholog_one2one ) |
| Ohnologs | SERPINE2, SERPINI1 |
| Paralogs | SERPING1, SERPINB7, SERPINF1, SERPINI1, AGT, SERPIND1, SERPINA7, SERPINB8, SERPINA6, SERPINI2, HMSD, SERPINB6, SERPINC1, SERPINB1, SERPINA10, SERPINH1, SERPINB13, SERPINA3, SERPINA5, SERPINA9, SERPINA12, SERPINF2, SERPINA4, SERPINB11, SERPINB5, SERPINB12, SERPINB9, SERPINE3, SERPINB4, SERPINB3, SERPINE2, SERPINA1, SERPINA2, SERPINB10, SERPINA11, SERPINB2 |
| Tissue | NA |
| Tissue Specificity | Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells. {ECO:0000269|PubMed:2430793, ECO:0000269|PubMed:3097076}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.006990(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A7C (X-ray 1.95A ) 1B3K (X-ray 2.99A ) 1C5G (X-ray 2.60A ) 1DB2 (X-ray 2.70A ) 1DVM (X-ray 2.40A ) 1DVN (X-ray 2.10A ) 1LJ5 (X-ray 1.80A ) 1OC0 (X-ray 2.28A ) 3CVM (X-ray 2.02A ) 3EOX (X-ray 2.61A ) 3PB1 (X-ray 2.30A ) 3Q02 (X-ray 2.30A ) 3Q03 (X-ray 2.64A ) 3R4L (X-ray 2.70A ) 3UT3 (X-ray 2.42A ) 4AQH (X-ray 2.40A ) 4G8O (X-ray 2.71A ) 4G8R (X-ray 2.19A ) 4IC0 (X-ray 2.32A ) 5BRR (X-ray 3.16A ) 5ZLZ (X-ray 3.58A ) 6GWN (X-ray 2.03A ) 6GWP (X-ray 2.28A ) 6GWQ (X-ray 2.32A ) 6I8S (X-ray 2.90A ) 6ZRV (X-ray 1.88A ) 7AQF (X-ray 1.77A ) 7AQG (X-ray 2.27A ) 9PAI (X-ray 2.70A ) |
| DBSNP | rs6092 rs6090 rs2227647 rs2227669 rs2227685 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:2430793}. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |