| Gene Information | |
|---|---|
| Gene Name | NCKAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1128 |
| Protein Names | Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000061676 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y2A7 |
| Gene Card | NCKAP1 |
| Uniprot ID | Q9Y2A7 |
| Pfam | PF09735 |
| In ASD | no |
| Allosteric Prediction | no (-0.493207805) |
| Ortholog in Animals | Alpaca_ NCKAP1 ( ortholog_one2one ) Dog_ NCKAP1 ( ortholog_one2one ) GuineaPig_ NCKAP1 ( ortholog_one2one ) Macaque_ NCKAP1 ( ortholog_one2one ) Mouse_ Nckap1 ( ortholog_one2one ) Pig_ NCKAP1 ( ortholog_one2one ) Rat_ Nckap1 ( ortholog_one2one ) Rabbit_ NCKAP1 ( ortholog_one2one ) |
| Ohnologs | NCKAP1L |
| Paralogs | NCKAP1L |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle. Expressed in cells of various brain regions including Purkinje cells and dentate nucleus of the cerebellum, CA4 region and dentate gyrus of the hippocampus, and in frontal gray and white matter (PubMed:28940097). {ECO:0000269|PubMed:28940097}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3P8C (X-ray 2.29A ) 4N78 (X-ray 2.43A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P28660}; Single-pass membrane protein {ECO:0000250|UniProtKB:P28660}; Cytoplasmic side {ECO:0000250|UniProtKB:P28660}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:P28660}; Single-pass membrane protein {ECO:0000250|UniProtKB:P28660}; Cytoplasmic side {ECO:0000250|UniProtKB:P28660}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250|UniProtKB:P28660}. |
| Mouse PG classification | NA |
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