Gene Information
Gene NameTNFSF15
OrganismHomo sapiens (Human)
Gene Length251
Protein NamesTumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) [Cleaved into: Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form]
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000181634 )
Evolutionary StageVertebrata
AlphaFoldDBO95150
Gene CardTNFSF15
Uniprot IDO95150
PfamPF00229
In ASDno
Allosteric Predictionno (-0.487877607)
Ortholog in AnimalsAlpaca_ TNFSF15 ( ortholog_one2one )
GuineaPig_ TNFSF15 ( ortholog_one2one )
Macaque_ TNFSF15 ( ortholog_one2one )
Mouse_ Tnfsf15 ( ortholog_one2one )
Pig_ TNFSF15 ( ortholog_one2one )
Rat_ Tnfsf15 ( ortholog_one2one )
Rabbit_ TNFSF15 ( ortholog_one2one )
OhnologsNA
ParalogsLTB, LTA, TNF, TNFSF14, FASLG, TNFSF10, TNFSF11, CD40LG
TissueNA
Tissue SpecificitySpecifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. {ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9434163, ECO:0000269|PubMed:9872942}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2O0O  (X-ray  3.00A  )  2QE3  (X-ray  2.50A  )  2RE9  (X-ray  2.10A  )  2RJK  (X-ray  2.30A  )  2RJL  (X-ray  2.05A  )  3K51  (X-ray  2.45A  )  3MI8  (X-ray  2.95A  ) 
DBSNP rs16931745 
Subcellular location [CC]Membrane {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219};
Single-pass type II membrane protein {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}.;
[Tumor necrosis factor ligand superfamily member 15, secreted form]: Secreted.
Mouse PG classificationNA
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