Gene Information
Gene NameHTRA2
OrganismHomo sapiens (Human)
Gene Length458
Protein NamesSerine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000115317 )
Evolutionary StageCellular_organisms
AlphaFoldDBO43464
Gene CardHTRA2
Uniprot IDO43464
PfamPF17820; PF02163
In ASDno
Allosteric Predictionyes (0.182256539)
Ortholog in AnimalsAlpaca_ HTRA2 ( ortholog_one2one )
Dog_ HTRA2 ( ortholog_one2one )
GuineaPig_ HTRA2 ( ortholog_one2one )
Macaque_ HTRA2 ( ortholog_one2one )
Mouse_ Htra2 ( ortholog_one2one )
Pig_ HTRA2 ( ortholog_one2one )
Rat_ Htra2 ( ortholog_one2one )
Rabbit_ HTRA2 ( ortholog_one2one )
OhnologsHTRA1, HTRA4, HTRA3
ParalogsHTRA4, HTRA1, HTRA3
TissueNA
Tissue Specificity[Isoform 1]: Ubiquitously expressed. {ECO:0000269|PubMed:10644717}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.028571(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1LCY  (X-ray  2.00A  )  2PZD  (X-ray  2.75A  )  5FHT  (X-ray  1.95A  )  5M3N  (X-ray  1.65A  )  5M3O  (X-ray  1.70A  )  5TNY  (X-ray  1.70A  )  5TNZ  (X-ray  1.75A  )  5TO0  (X-ray  1.90A  )  5TO1  (X-ray  1.69A  )  5WYN  (X-ray  2.05A  )  7VGE  (X-ray  4.00A  ) 
DBSNP rs775840965  rs150047108  rs757704467  rs72470544  rs375322953  rs1057519082  rs72470545  rs767006508  rs1380794702 
Subcellular location [CC]Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305};
Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.;
[Isoform 1]: Endoplasmic reticulum {ECO:0000269|PubMed:10644717}.
Mouse PG classificationHPG
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