| Gene Information | |
|---|---|
| Gene Name | HTR7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 479 |
| Protein Names | 5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (Serotonin receptor 7) |
| Target Name | 5-ht 7 receptor |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000148680 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P34969 |
| Gene Card | HTR7 |
| Uniprot ID | P34969 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.472154699) |
| Ortholog in Animals | Alpaca_ HTR7 ( ortholog_one2one ) Dog_ HTR7 ( ortholog_one2one ) GuineaPig_ HTR7 ( ortholog_one2one ) Macaque_ HTR7 ( ortholog_one2one ) Mouse_ Htr7 ( ortholog_one2one ) Pig_ HTR7 ( ortholog_one2one ) Rat_ Htr7 ( ortholog_one2one ) Rabbit_ HTR7 ( ortholog_one2one ) |
| Ohnologs | ADRA1D, ADRA1A, HTR1B, HTR5A, HTR4, ADRA1B |
| Paralogs | HTR6, HTR5A, HTR1E, HTR1B, HTR1F, HTR2C, HTR2A, HTR2B |
| Tissue | testis |
| Tissue Specificity | Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in terms of expression. {ECO:0000269|PubMed:9084407}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 7XTC (EM 3.20A ) |
| DBSNP | rs1379762209 rs114969659 rs33954285 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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