| Gene Information | |
|---|---|
| Gene Name | TFE3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 575 |
| Protein Names | Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000068323 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P19532 |
| Gene Card | TFE3 |
| Uniprot ID | P19532 |
| Pfam | PF11851; PF00010; PF15951 |
| In ASD | no |
| Allosteric Prediction | no (-0.007231721) |
| Ortholog in Animals | Alpaca_ TFE3 ( ortholog_one2one ) Dog_ TFE3 ( ortholog_one2one ) GuineaPig_ TFE3 ( ortholog_one2one ) Macaque_ TFE3 ( ortholog_one2one ) Mouse_ Tfe3 ( ortholog_one2one ) Pig_ TFE3 ( ortholog_one2one ) Rat_ Tfe3 ( ortholog_one2one ) Rabbit_ TFE3 ( ortholog_one2one ) |
| Ohnologs | TFEB, MITF |
| Paralogs | TFEB, TFEC, MITF |
| Tissue | NA |
| Tissue Specificity | Ubiquitous in fetal and adult tissues. {ECO:0000269|PubMed:8986805}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7F09 (X-ray 2.60A ) |
| DBSNP | rs5953258 rs3027470 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:30733432}. Nucleus {ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:30733432}. Note=When nutrients are present, phosphorylation by MTOR prevents nuclear translocation and activity (PubMed:22692423, PubMed:30733432). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:22692423, PubMed:30733432). {ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:30733432}. |
| Mouse PG classification | NA |
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