| Gene Information | |
|---|---|
| Gene Name | HTR3A |
| Organism | Homo sapiens (Human) |
| Gene Length | 478 |
| Protein Names | 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor) |
| Target Name | 5-ht 3a receptor |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000166736 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P46098 |
| Gene Card | HTR3A |
| Uniprot ID | P46098 |
| Pfam | PF02931; PF02932 |
| In ASD | yes |
| Allosteric Prediction | yes (1.187803763) |
| Ortholog in Animals | Alpaca_ HTR3A ( ortholog_one2one ) Dog_ HTR3A ( ortholog_one2one ) GuineaPig_ HTR3A ( ortholog_one2one ) Macaque_ HTR3A ( ortholog_one2one ) Mouse_ Htr3a ( ortholog_one2one ) Pig_ HTR3A ( ortholog_one2one ) Rat_ Htr3a ( ortholog_one2one ) Rabbit_ HTR3A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB |
| Tissue | NA |
| Tissue Specificity | Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. {ECO:0000269|PubMed:10521471}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs117793058 rs4938063 rs35815285 rs183698487 |
| Subcellular location [CC] | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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