| Gene Information | |
|---|---|
| Gene Name | KCNC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 511 |
| Protein Names | Potassium voltage-gated channel subfamily C member 1 (NGK2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4) |
| Target Name | potassium voltage-gated channel subfamily c member 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000129159 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P48547 |
| Gene Card | KCNC1 |
| Uniprot ID | P48547 |
| Pfam | PF02214; PF00520 |
| In ASD | no |
| Allosteric Prediction | yes (0.424634502) |
| Ortholog in Animals | Alpaca_ KCNC1 ( ortholog_one2one ) Dog_ KCNC1 ( ortholog_one2one ) GuineaPig_ KCNC1 ( ortholog_one2one ) Macaque_ KCNC1 ( ortholog_one2one ) Mouse_ Kcnc1 ( ortholog_one2one ) Pig_ KCNC1 ( ortholog_one2one ) Rat_ Kcnc1 ( ortholog_one2one ) Rabbit_ KCNC1 ( ortholog_one2one ) |
| Ohnologs | KCNC3, KCNC2, KCNC4 |
| Paralogs | KCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2 |
| Tissue | brain, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7PHH (EM 3.20A ) 7PHI (EM 3.10A ) 7PHK (EM 3.10A ) 7PHL (EM 3.20A ) 7PQT (EM 2.65A ) 7PQU (EM 3.03A ) |
| DBSNP | rs727502818 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:25401298}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P25122}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P25122}. Note=Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. {ECO:0000250|UniProtKB:P25122}. |
| Mouse PG classification | NA |
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