| Gene Information | |
|---|---|
| Gene Name | HTR2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 481 |
| Protein Names | 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B) |
| Target Name | 5-ht 2b receptor |
| Target Type | Successful target |
| Gene Age | 886 ( ENSG00000135914 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P41595 |
| Gene Card | HTR2B |
| Uniprot ID | P41595 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.410651011) |
| Ortholog in Animals | Alpaca_ HTR2B ( ortholog_one2one ) Dog_ HTR2B ( ortholog_one2one ) GuineaPig_ HTR2B ( ortholog_one2one ) Macaque_ HTR2B ( ortholog_one2one ) Mouse_ Htr2b ( ortholog_one2one ) Pig_ HTR2B ( ortholog_one2one ) Rat_ Htr2b ( ortholog_one2one ) Rabbit_ HTR2B ( ortholog_one2one ) |
| Ohnologs | HTR2A, HTR2C |
| Paralogs | HTR2C, HTR2A, HTR5A, HTR1E, HTR1B, HTR1F, HTR7, HTR6 |
| Tissue | adrenal.gland, endometrium, smooth.muscle |
| Tissue Specificity | Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex. {ECO:0000269|PubMed:21179162, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856, ECO:0000269|PubMed:8882600}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4IB4 (X-ray 2.70A ) 4NC3 (X-ray 2.80A ) 5TUD (X-ray 3.00A ) 5TVN (X-ray 2.90A ) 6DRX (X-ray 3.10A ) 6DRY (X-ray 2.92A ) 6DRZ (X-ray 3.10A ) 6DS0 (X-ray 3.19A ) |
| DBSNP | rs78484969 rs77570025 rs77982984 rs6736017 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856}; Multi-pass membrane protein {ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q02152}. |
| Mouse PG classification | NA |
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