| Gene Information | |
|---|---|
| Gene Name | HTR1E |
| Organism | Homo sapiens (Human) |
| Gene Length | 365 |
| Protein Names | 5-hydroxytryptamine receptor 1E (5-HT-1E) (5-HT1E) (S31) (Serotonin receptor 1E) |
| Target Name | 5-ht 1e receptor |
| Target Type | Successful target |
| Gene Age | 886 ( ENSG00000168830 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P28566 |
| Gene Card | HTR1E |
| Uniprot ID | P28566 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.022251932) |
| Ortholog in Animals | Alpaca_ HTR1E ( ortholog_one2one ) Dog_ HTR1E ( ortholog_one2one ) GuineaPig_ HTR1E ( ortholog_one2one ) Macaque_ HTR1E ( ortholog_one2one ) Pig_ HTR1E ( ortholog_one2one ) Rabbit_ HTR1E ( ortholog_one2one ) |
| Ohnologs | DRD3, HTR1A, HTR1F, HTR1D |
| Paralogs | HTR1F, HTR1B, HTR5A, HTR7, HTR6, HTR2C, HTR2A, HTR2B |
| Tissue | amygdala, caudate.nucleus, cerebellum, middle.temporal.gyrus, olfactory.apparatus, parietal.lobe, pineal.gland, putamen |
| Tissue Specificity | Detected in brain. {ECO:0000269|PubMed:14744596}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 7E33 (EM 2.90A ) |
| DBSNP | rs3828741 rs6303 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}; Multi-pass membrane protein {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}. |
| Mouse PG classification | NA |
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