| Gene Information | |
|---|---|
| Gene Name | TIMELESS |
| Organism | Homo sapiens (Human) |
| Gene Length | 1208 |
| Protein Names | Protein timeless homolog (hTIM) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000111602 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UNS1 |
| Gene Card | TIMELESS |
| Uniprot ID | Q9UNS1 |
| Pfam | PF04821; PF05029 |
| In ASD | no |
| Allosteric Prediction | no (-0.12742712) |
| Ortholog in Animals | Alpaca_ TIMELESS ( ortholog_one2one ) GuineaPig_ TIMELESS ( ortholog_one2one ) Macaque_ TIMELESS ( ortholog_one2one ) Mouse_ Timeless ( ortholog_one2one ) Pig_ TIMELESS ( ortholog_one2one ) Rat_ Timeless ( ortholog_one2one ) Rabbit_ TIMELESS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis. {ECO:0000269|PubMed:9856465, ECO:0000269|PubMed:9891984}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.169777(Rat);0.128203(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4XHT (X-ray 1.65A ) 4XHU (X-ray 2.09A ) 4XHW (X-ray 2.85A ) 5MQI (X-ray 1.85A ) 6T9Q (X-ray 1.15A ) 6TAZ (NMR - ) 7PFO (EM 3.20A ) 7PLO (EM 2.80A ) |
| DBSNP | rs72478986 rs774027 rs72478993 rs774047 rs61733875 rs72478999 rs72479000 rs151188513 rs61376834 rs2291739 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17141802}. Chromosome {ECO:0000269|PubMed:26344098}. Note=In response to double-strand breaks (DSBs), accumulates at DNA damage sites via its interaction with PARP1. {ECO:0000269|PubMed:26344098}. |
| Mouse PG classification | NA |
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