| Gene Information | |
|---|---|
| Gene Name | SGPL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 568 |
| Protein Names | Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) |
| Target Name | sphingosine-1-phosphate lyase 1 |
| Target Type | Clinical trial target |
| Gene Age | 1714 ( ENSG00000166224 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O95470 |
| Gene Card | SGPL1 |
| Uniprot ID | O95470 |
| Pfam | PF00282 |
| In ASD | no |
| Allosteric Prediction | no (-0.039956039) |
| Ortholog in Animals | Alpaca_ SGPL1 ( ortholog_one2one ) Dog_ SGPL1 ( ortholog_one2one ) GuineaPig_ SGPL1 ( ortholog_one2one ) Macaque_ SGPL1 ( ortholog_one2one ) Mouse_ Sgpl1 ( ortholog_one2one ) Pig_ SGPL1 ( ortholog_one2one ) Rat_ Sgpl1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CSAD, DDC, PDXDC1, HDC, GAD1, GADL1, GAD2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (PubMed:11018465, PubMed:28165343). Expressed in fetal and adult adrenal gland (at protein level) (PubMed:28165343). {ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:28165343}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4Q6R (X-ray 2.40A ) |
| DBSNP | rs12770335 rs201533115 rs769259446 rs1131692255 rs1437439236 rs1131692256 rs779485098 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:14570870}; Single-pass type III membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R0X7}. |
| Mouse PG classification | NA |
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