| Gene Information | |
|---|---|
| Gene Name | HTR1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 422 |
| Protein Names | 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (G-21) (Serotonin receptor 1A) |
| Target Name | 5-ht 1a receptor |
| Target Type | Successful target |
| Gene Age | 950 ( ENSG00000178394 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08908 |
| Gene Card | HTR1A |
| Uniprot ID | P08908 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.497303511) |
| Ortholog in Animals | Alpaca_ HTR1A ( ortholog_one2one ) GuineaPig_ HTR1A ( ortholog_one2one ) Macaque_ HTR1A ( ortholog_one2one ) Mouse_ Htr1a ( ortholog_one2one ) Pig_ HTR1A ( ortholog_one2one ) Rabbit_ HTR1A ( ortholog_one2one ) |
| Ohnologs | HTR1B, HTR1E, ADRA1B, HTR1F |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, CHRM2, GPR161, DRD5, TAAR2, HTR1D |
| Tissue | NA |
| Tissue Specificity | Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells. {ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:8393041}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7E2X (EM 3.00A ) 7E2Y (EM 3.00A ) 7E2Z (EM 3.10A ) |
| DBSNP | rs1800041 rs1799920 rs1799921 rs1800043 rs1800044 rs1800042 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}; Multi-pass membrane protein {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}. Cell projection, dendrite {ECO:0000250|UniProtKB:P19327}. |
| Mouse PG classification | NA |
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