Gene Information
Gene NameHTATIP
OrganismHomo sapiens (Human)
Gene Length513
Protein NamesHistone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ92993
Gene CardKAT5
Uniprot IDQ92993
PfamPF01853; PF11717; PF17772
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2EKO  (NMR  -  )  2OU2  (X-ray  2.30A  )  4QQG  (X-ray  2.80A  ) 
DBSNP rs1857071943  rs11541271  rs1857290083 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:11262386, ECO:0000269|PubMed:11416127, ECO:0000269|PubMed:12551922, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17704809, ECO:0000269|PubMed:17996965, ECO:0000269|PubMed:25301942, ECO:0000269|PubMed:33938178}. Chromosome {ECO:0000269|PubMed:25560918, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:29335245, ECO:0000269|PubMed:33076429}. Cytoplasm {ECO:0000269|PubMed:25301942}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:26829474}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:34608293}. Nucleus, nucleolus {ECO:0000269|PubMed:16387653}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11262386}. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies (PubMed:11262386). Transiently localizes to kinetochores in early mitosis (PubMed:26829474). Localizes to spindle poles when chromosomes align during metaphase (PubMed:34608293). Localizes in the cytoplasm and nucleus of round spermatids (By similarity). {ECO:0000250|UniProtKB:Q8CHK4, ECO:0000269|PubMed:11262386, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:34608293}.
Mouse PG classificationNA
click here to return to the previous page