| Gene Information | |
|---|---|
| Gene Name | FATE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 183 |
| Protein Names | Fetal and adult testis-expressed transcript protein (Cancer/testis antigen 43) (CT43) (Tumor antigen BJ-HCC-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000147378 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q969F0 |
| Gene Card | FATE1 |
| Uniprot ID | Q969F0 |
| Pfam | PF05644 |
| In ASD | no |
| Allosteric Prediction | no (-1.464774064) |
| Ortholog in Animals | Alpaca_ FATE1 ( ortholog_one2many ) Dog_ FATE1 ( ortholog_one2one ) Macaque_ FATE1 ( ortholog_one2one ) Mouse_ Fate1 ( ortholog_one2one ) Pig_ FATE1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | testis |
| Tissue Specificity | Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919). {ECO:0000269|PubMed:11694338, ECO:0000269|PubMed:12865919}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3810715 rs141497002 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:26567849, ECO:0000269|PubMed:27402544}. Mitochondrion outer membrane {ECO:0000269|PubMed:27402544}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27402544}; Single-pass membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:27402544}. Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER. {ECO:0000269|PubMed:27402544}. |
| Mouse PG classification | NA |
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