Gene Information
Gene NameVTCN1
OrganismHomo sapiens (Human)
Gene Length282
Protein NamesV-set domain-containing T-cell activation inhibitor 1 (B7 homolog 4) (B7-H4) (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x)
Target NameNA
Target TypeNA
Gene Age454 ( ENSG00000134258 )
Evolutionary StageVertebrata
AlphaFoldDBQ7Z7D3
Gene CardVTCN1
Uniprot IDQ7Z7D3
PfamPF07686
In ASDno
Allosteric Predictionno (-0.502121953)
Ortholog in AnimalsAlpaca_ VTCN1 ( ortholog_one2one )
Dog_ VTCN1 ( ortholog_one2one )
GuineaPig_ VTCN1 ( ortholog_one2one )
Mouse_ Vtcn1 ( ortholog_one2one )
Pig_ VTCN1 ( ortholog_one2one )
Rat_ Vtcn1 ( ortholog_one2one )
Rabbit_ VTCN1 ( ortholog_one2one )
OhnologsNA
ParalogsBTN2A2, CD276, BTNL2, BTN2A1, BTNL9, ICOSLG, ERMAP, HHLA2, BTN1A1, BTN3A3, BTN3A2, BTN3A1, MOG, BTNL3, BTNL8
Tissueoviduct, epididymis, kidney, pancreas
Tissue SpecificityOverexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:14568939, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:16782226, ECO:0000269|PubMed:16798883, ECO:0000269|PubMed:17509674}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4GOS  (X-ray  1.59A  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000255};
Single-pass type I membrane protein {ECO:0000305}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}.
Mouse PG classificationNA
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