| Gene Information | |
|---|---|
| Gene Name | P2RX3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 397 |
| Protein Names | P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor) |
| Target Name | p2x purinoceptor 3 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000109991 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P56373 |
| Gene Card | P2RX3 |
| Uniprot ID | P56373 |
| Pfam | NA |
| In ASD | yes |
| Allosteric Prediction | yes (0.99983402) |
| Ortholog in Animals | Alpaca_ P2RX3 ( ortholog_one2one ) Dog_ P2RX3 ( ortholog_one2one ) GuineaPig_ P2RX3 ( ortholog_one2one ) Macaque_ P2RX3 ( ortholog_one2one ) Mouse_ P2rx3 ( ortholog_one2one ) Pig_ P2RX3 ( ortholog_one2one ) Rat_ P2rx3 ( ortholog_one2one ) Rabbit_ P2RX3 ( ortholog_one2one ) |
| Ohnologs | P2RX6, P2RX1, P2RX4, P2RX2 |
| Paralogs | P2RX2, P2RX6, P2RX5, P2RX1, P2RX7, P2RX4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5SVJ (X-ray 2.98A ) 5SVK (X-ray 2.77A ) 5SVL (X-ray 2.90A ) 5SVM (X-ray 3.09A ) 5SVP (X-ray 3.30A ) 5SVQ (X-ray 3.25A ) 5SVR (X-ray 3.13A ) 5SVS (X-ray 4.03A ) 5SVT (X-ray 3.79A ) 5YVE (X-ray 3.40A ) 6AH4 (X-ray 3.30A ) 6AH5 (X-ray 3.82A ) |
| DBSNP | rs2276038 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:27626375}; Multi-pass membrane protein {ECO:0000269|PubMed:27626375}. |
| Mouse PG classification | NA |
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