| Gene Information | |
|---|---|
| Gene Name | SYNCRIP |
| Organism | Homo sapiens (Human) |
| Gene Length | 623 |
| Protein Names | Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000135316 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60506 |
| Gene Card | SYNCRIP |
| Uniprot ID | O60506 |
| Pfam | PF18360; PF00076 |
| In ASD | no |
| Allosteric Prediction | yes (0.024107032) |
| Ortholog in Animals | Alpaca_ SYNCRIP ( ortholog_one2one ) Alpaca_ SYNCRIP ( ortholog_one2many ) Dog_ SYNCRIP ( ortholog_one2one ) GuineaPig_ SYNCRIP ( ortholog_one2one ) Macaque_ SYNCRIP ( ortholog_one2one ) Mouse_ Syncrip ( ortholog_one2one ) Pig_ SYNCRIP ( ortholog_one2one ) Rat_ Syncrip ( ortholog_one2one ) Rabbit_ SYNCRIP ( ortholog_one2one ) |
| Ohnologs | HNRNPR |
| Paralogs | HNRNPR, RBMS2, PABPC1, PABPC3, RBM24, ELAVL4, ELAVL3, RBMS1, ELAVL2, PUF60, RBM34, RBM45, PABPC1L, PABPC5, RBM14, PABPC1L2A, PABPC1L2B, SF3B4, RBM38, ELAVL1, TARDBP, RBMS3, PABPC4, PABPC4L |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis. {ECO:0000269|PubMed:11352648}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004890(Rat);0.014085(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DGU (NMR - ) 2MXT (NMR - ) 2NBB (NMR - ) 6KOR (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:35538151}. Microsome {ECO:0000250|UniProtKB:Q7TMK9}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250|UniProtKB:Q7TMK9}. Note=The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). {ECO:0000250|UniProtKB:O43390, ECO:0000250|UniProtKB:Q7TMK9}.; [Isoform 1]: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TMK9}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250|UniProtKB:Q7TMK9}.; [Isoform 2]: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TMK9}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250|UniProtKB:Q7TMK9}.; [Isoform 3]: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TMK9}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250|UniProtKB:Q7TMK9}. |
| Mouse PG classification | NA |
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